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Epitope dominance conferred by a Db transgene. The staining patterns of CNS-ILs isolated from resistant FVB (H-2Db) transgenic mice (A) and susceptible, parental FVB (H-2q) mice (B) are shown. CNS-ILs were stained with Db:VP2121–130 tetramer and anti-CD8 antibodies and analyzed by FACS. The percentage of CD8+ T cells that are double positive is given in the upper right corner of panel A.
