Table 5. Oral Chemotherapy Administration Recommendations.
| Oral chemotherapy agent | Recommendation | |
|---|---|---|
| Abemaciclib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Abiraterone | Zytiga: Take on empty stomach at least 1 hr before or at least 2 hr after food Yonsa: Take with or without food |
NA |
| Acalabrutinib | Take with or without food | NA |
| Adagrasib | Take with or without food | NA |
| Afatinib | Take on empty stomach at least 1 hr before or at least 2 hrs after food | NA |
| Alectinib | Take with food | NA |
| Alpelisib | Take with food | NA |
| Apalutamide | Take with or without food | NA |
| Asciminib | Take on empty stomach at least 2 hr before or at least 1 hr after food | NA |
| Avapritinib | Take on empty stomach at least 1 hr before or at least 2 hr after food | NA |
| Axitinib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Azacitidine | Take with or without food | NA |
| Bexarotene | Take with food | NA |
| Binimetinib | Take with or without food | NA |
| Bosutinib | Take with food | Avoid grapefruit and grapefruit juice |
| Brigatinib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Cabozantinib | Take on empty stomach at least 1 hr before or at least 2 hr after food | Avoid grapefruit and grapefruit juice |
| Capecitabine | Take within 30 minutes after meal | NA |
| Capmatinib | Take with or without food | NA |
| Ceritinib | Take with food (450-mg dose) | Avoid grapefruit and grapefruit juice |
| Chlorambucil | Take on empty stomach | NA |
| Cobimetinib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Crizotinib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Cyclophosphamide | Take with or without food | NA |
| Dabrafenib | Take on empty stomach at least 1 hr before or at least 2 hr after food | NA |
| Dacomitinib | Take with or without food | NA |
| Darolutamide | Take with food | NA |
| Dasatinib | Take with or without food. May take with food if stomach upset | Avoid grapefruit and grapefruit juice |
| Decitabine/cedazuridine | Take on empty stomach at least 2 hr before or at least 2 hr after food | NA |
| Duvelisib | Take with or without food | NA |
| Enasidenib | Take with or without food | NA |
| Encorafenib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Entrectinib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Enzalutamide | Take with or without food | NA |
| Erdafitinib | Take with or without food | NA |
| Erlotinib | Take on empty stomach at least 1 hr before or at least 2 hr after food | Avoid grapefruit and grapefruit juice |
| Etoposide | Take with or without food | NA |
| Everolimus | Take with or without food, but should be consistent | Avoid grapefruit and grapefruit juice |
| Fedratinib | Take with or without food, but a higher-fat meal decreases GI upset | NA |
| Futibatinib | Take with or without food | NA |
| Gefitinib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Gilteritinib | Take with or without food | NA |
| Glasdegib | Take with or without food | NA |
| Ibrutinib | Take with or without food | Avoid grapefruit, grapefruit juice, and Seville oranges |
| Idelalisib | Take with or without food | NA |
| Imatinib | Take with food to reduce GI upset | Avoid grapefruit and grapefruit juice |
| Infigratinib | Take on empty stomach at least 1 hr before or at least 2 hr after food | NA |
| Ivosidenib | Take with or without food | NA |
| Ixazomib | Take on empty stomach at least 1 hr before or at least 2 hr after food | NA |
| Lapatinib | Take on empty stomach at least 1 hr before or at least 2 hr after food | Avoid grapefruit and grapefruit juice |
| Larotrectinib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Lenalidomide | Take with or without food | NA |
| Lenvatinib | Take with or without food | NA |
| Lomustine | Take on empty stomach to reduce nausea | NA |
| Lorlatinib | Take with or without food | NA |
| Melphalan | Take on empty stomach to enhance oral absorption | NA |
| Mercaptopurine | Take with or without food | NA |
| Methotrexate | Take with or without food | NA |
| Midostaurin | Take with or without food | Avoid grapefruit and grapefruit juice |
| Mitotane | Take with or without food | NA |
| Mobocertinib | Take with or without food | NA |
| Neratinib | Take with food | Avoid grapefruit and grapefruit juice |
| Nilotinib | Take on empty stomach at least 1 hr before or at least 2 hr after food | Avoid grapefruit and grapefruit juice |
| Niraparib | Take with or without food | NA |
| Olaparib | Take with or without food | Avoid grapefruit, grapefruit juice, and Seville oranges |
| Olutasidenib | Take on empty stomach at least 1 hr before or at least 2 hr after food | NA |
| Osimertinib | Take with or without food | NA |
| Pacritinib | Take with or without food | NA |
| Palbociclib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Pazopanib | Take on empty stomach at least 1 hr before or at least 2 hr after food | Avoid grapefruit and grapefruit juice |
| Pemigatinib | Take with or without food | NA |
| Pexidartinib | Take on empty stomach at least 1 hr before or at least 2 hr after food | Avoid grapefruit and grapefruit juice |
| Pomalidomide | Take with or without food | NA |
| Ponatinib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Pralsetinib | Take on empty stomach at least 1 hr before or at least 2 hr after food | NA |
| Procarbazine | Take with or without food. Avoid alcohol and tyramine-containing foods to reduce adverse effects | NA |
| Ribociclib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Ripretinib | Take with or without food | NA |
| Rucaparib | Take with or without food | NA |
| Ruxolitinib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Selinexor | Take with or without food | NA |
| Selpercatinib | Take with or without food | NA |
| Selumetinib | Take on empty stomach at least 2 hr before or at least 1 hr after food | NA |
| Sonidegib | Take on empty stomach at least 1 hr before or at least 2 hr after food | NA |
| Sorafenib | Take on empty stomach at least 1 hr before or at least 2 hr after food | NA |
| Sotorasib | Take with or without food | NA |
| Sunitinib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Talazoparib | Take with or without food | NA |
| Tazemetostat | Take with or without food | NA |
| Temozolomide | Take on empty stomach to reduce GI upset | NA |
| Tepotinib | Take with food | NA |
| Thalidomide | Take at least 1 hr after evening meal | NA |
| Thioguanine | Take with or without food | NA |
| Tivozanib | Take with or without food | NA |
| Topotecan | Take with or without food | NA |
| Trametinib | Take on empty stomach at least 1 hr before or at least 2 hrs after food | NA |
| Tretinoin | Take with food to enhance oral absorption | NA |
| Trifluridine/tipiracil | Take with food | NA |
| Tucatinib | Take with or without food | NA |
| Umbralisib | Take with food | NA |
| Vandetanib | Take with or without food | NA |
| Vemurafenib | Take with or without food | Avoid grapefruit and grapefruit juice |
| Venetoclax | Take with food | Avoid grapefruit, grapefruit juice, and Seville oranges |
| Vismodegib | Take with or without food | NA |
| Vorinostat | Take with food | NA |
| Zanubrutinib | Take with or without food | Avoid grapefruit, grapefruit juice, and Seville oranges |
Note. NA = not applicable. Information from Lexicomp (2022).