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Hematoxylin and Eosin stain of the needle core biopsy with exocrine pancreatic lobule showing partial atrophy. An endocrine islet is noted (arrow). The aggregates of small “blue cells” represents an infiltrative neuroendocrine tumor. Tumor cells stain strongly positive for the neuroendocrine markers INSM1 and CD56. Weaker staining in the lower right image, noted by arrow, demonstrates endocrine islet. Bar: 200 µm.
