Kaplan-Meier curves of (A) OS and (B) rPFS according to the standard definition of progression (PCWG), (C) the PCWG definition with the addition of clinical progression, and (D) the PCWG definition with the addition of post-treatment radiographic progression of disease. AAP, abiraterone acetate and prednisone; enza, enzalutamide; HR, hazard ratio; OS, overall survival; PCWG, Prostate Cancer Clinical Trials Working Group; rPFS, radiographic progression-free survival; RUCP, radiographic and unequivocal clinical progression.