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. 2023 Aug 9;9(9):e1516. doi: 10.1097/TXD.0000000000001516

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Copyright © 2023 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 1. — Experimental design. Orthotopic left lung transplantation was performed from Brown-Norway donor rats to major histocompatibility complex–mismatched Lewis recipient rats. The treatment NAD⁺ group (n = 8) received NAD⁺ intraperitoneally 4 h pretransplant and on days 1, 2, 3, and 4 after transplantation, whereas the control group (n = 8) received saline as placebo (symbolized by syringes). An additional syngraft group (n = 2) of Lewis recipients and Lewis donors was treated as the control group with placebo. NAD+, β-nicotinamide adenine dinucleotide.