TABLE 1.
BAL and plasma cytokines, chemokines, and mediators of wound healing and tissue repair at 5 d posttransplantation in the study groups
| BAL | BAL | BAL | Plasma | Plasma | Plasma | |
|---|---|---|---|---|---|---|
| Control (N = 8) | NAD+ (N = 8) | Lew/Lew (N = 2) | Control (N = 8) | NAD+ (N = 8) | Lew/Lew (N = 2) | |
| EGF | 17.02 (21.66) | 14.38 (21.21) | 2.04 (1.29) | 84.62 (77.43) | 33.92 (35.35) | 0.14 (0.16) |
| Eotaxin | 5.199 (3.068) | 4.803 (3.661) | 1.474 (1.119) | 14.09 (11.39) | 12.08 (3.09) | 11.25 (4.05) |
| Fractalkine | 54.58 (42.09) | 94.33 (72.31) | 45.43 (48.52) | 132.5 (50.35) | 164.3 (41.81) | 100.5 (41.38) |
| G-CSF | 7.784 (7.852) | 5.862 (4.062) | 3.375 (0.697) | 32.76 (22.63) | 40.51 (34.49) | 26.43 (1.39) |
| GM-CSF | 20.40 (17.69) | 12.71 (9.61) | 8.02 (0.86) | 112.4 (25.8) | 129.8 (44.16) | 172.8 (2.02) |
| GRO/KC | 29.96 (41.33) | 62.61 (53.30) | 14.61 (6.80) | 863.3 (542.9) | 334.1 (203.2)* | 516.0 (74.51) |
| IFNγ | 497.9 (406.0) | 365.2 (305.8) | 103.0 (20.6) | 296.1 (116.8) | 443.0 (180.1) | 256.9 (76.0) |
| IL1-α | 67.81 (46.49) | 43.91 (28.49) | 22.58 (2.84) | 130.5 (222.7) | 88.6 (58.2) | 64.6 (11.8) |
| IL1-β | 268.6 (228.8) | 147.4 (85.7) | 35.3 (13.4) | 1201 (726) | 780 (288) | 1185 (1171) |
| IL-2 | 12.05 (6.66) | 17.03 (12.30) | 6.05 (0.98) | 114.3 (121.5) | 105.9 (105.7) | 62.0 (50.7) |
| IL-4 | 19.32 (9.18) | 17.98 (14.28) | 12 (0.08) | 34.42 (15.85) | 47.15 (32.40) | 30.29 (11.96) |
| IL-5 | 36.01 (14.04) | 23.18 (7.54) | 16.21 (0.56) | 53.17 (21.18) | 66.19 (40.01) | 64.28 (16.38) |
| IL-6 | 1546 (1937) | 106 (38)*** | 138 (94) | 2483 (1809) | 1354 (310) | 912 (92) |
| IL-10 | 107.8 (120.2) | 75.8 (82.2) | 11.7 (2.3) | 1044 (341) | 1022 (263) | 807 (510) |
| IL-12(p70) | 28.67 (11.65) | 26.32 (17.72) | 14.59 (5.71) | 96.7 (29.8) | 122.4 (90.7) | 124.8 (66.7) |
| IL-13 | 31.39 (13.93) | 13.95 (4.27)* | 12.62 (1.76) | 69.5 (104.8) | 45.4 (29.7) | 25.9 (0.5) |
| IL-17A | 58.01 (62.18) | 19.57 (16.94) | 5.97 (2.76) | 16.98 (8.03) | 31.81 (20.55) | 36.02 (19.62) |
| IL-18 | 1339 (1011) | 1305 (368) | 295 (155) | 1384(953) | 1385 (542) | 394 (273) |
| LIX | 534.6 (460.4) | 624.3 (763.0) | 71.1 (34.2) | 336.3 (226.1) | 630.8 (841.7) | 758.8 (480.0) |
| MCP-1 | 1593 (1612) | 499 (404) | 145 (2) | 785.9 (152.8) | 827.0 (183.0) | 742.2 (96.3) |
| MIP1-α | 51.41 (44.74) | 13.03 (4.72) | 2.89 (0.30) | 15.52 (10.20) | 15.18 (4.65) | 8.58 (3.35) |
| MIP-2 | 220.5 (405.5) | 41.2 (53.1) | 6.9 (2.8) | 86.44 (36.68) | 96.48 (33.35) | 141.30 (45.28) |
| Rantes | 266.3 (210.2) | 45.8 (22.6) | 2.87 (0.1) | 415.9 (109.5) | 466.2 (280.0) | 841.9 (477.5) |
| TNF-α | 6.596 (4.437) | 2.592 (0.906)* | 1.417 (0.103) | 8.725 (3.124) | 8.205 (4.710) | 7.915 (2.312) |
| VEGF | 312.9 (221.4) | 666.3 (1058.0) | 69.9 (1.5) | 184.8 (46.3) | 198.0 (36.1) | 107.3 (21.1) |
Summary of the means (M) and the SD for BAL and plasma in pg/mL. Note *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001. The stars are significant P valuess vs the control.
BAL, bronchoalveolar lavage; IFNγ, interferon gamma; IL, interleukin; MCP-1, monocyte chemoattractant protein-1; MIP, macrophage inflammatory protein; NAD+, β-nicotinamide adenine dinucleotide.