Table 3.
Reported chemotherapy toxicities for Carboplatin + Paclitaxel x8C subgroup, by age.
| Toxicity Category | Age < 70 (%) |
Age ≥ 70 (%) |
P |
|---|---|---|---|
| Leukopenia (≥G3) | 52.9 | 53.9 | 0.84 |
| Thrombocytopenia (≥G3) | 24.4 | 25.2 | 0.86 |
| Neutropenia (≥G4) | 62.2 | 67.8 | 0.25 |
| Anemia (≥G3) | 12.1 | 12.2 | 0.97 |
| GI (≥G3) | 9.5 | 13.9 | 0.15 |
| GU/renal (≥G2) | 5.8 | 4.3 | 0.54 |
| Peripheral neuropathy (≥G2) | 19.7 | 35.7 | <0.001 |
| Pain (≥G3) | 5.5 | 4.3 | 0.63 |
| Pulmonary (≥G3) | 2.4 | 2.6 | 0.90 |
| Hepatic (≥G2) | 4.7 | 4.3 | 0.89 |
| Infection (≥G3) | 8.8 | 11.3 | 0.40 |
| Auditory (≥G2) | 2.7 | 3.5 | 0.66 |
GI: gastrointestinal.
GU: genitourinary.
Chemotherapy toxicity rates were computed by age group and the rates were compared using Pearson’s Chi-squared test.