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. 2023 Aug 10;10(5):e200149. doi: 10.1212/NXI.0000000000200149

Figure 6. VK-1727 Disrupts EBNA1 Binding in SLCLs.

Figure 6

(A) ChIP assay for EBNA1 binding to the DS, Qp, and cellular locus CLIC1 in AMS4 SLCLs treated with DMSO or 30 µM VK-1727 for 72 hours. p values were determined for 3 biological replicates (***p < 0.001, Two-way ANOVA). (B) Immunoprecipitation was performed with IgG as a control bottom panel. (C) Expression of EBV latency (EBNA1, EBNA, EBER, LMP1) and lytic (Zta and EA-D) genes in EBV+ AMS4 SLCL. p values were determined for 3 biological replicates (*p < 0.05, t test). EBV = Epstein-Barr virus; SLCL = spontaneous lymphoblastoid line.