Table 4.
Effect of tourniquet utilization on target-site concentration
| Study (level of evidence) | Group | Tissue | Technique | Tissue concentration,* (AUC) | Above MIC |
|---|---|---|---|---|---|
| Friedrich et al.28 (prospective study) n = 24 |
HPLC | ||||
| 1 min | Soft tissues | 224 (21–408) | Yes | ||
| Bone | 200 (79–617) | Yes | |||
| Serum | 4699 (1328–8266) | Yes | |||
| 2 min | Soft tissues | 387 (133–533) | Yes | ||
| Bone | 182 (93–277) | Yes | |||
| Serum | 5170 (1301–26 272) | Yes | |||
| 5 min | Soft tissues | 671 (489–2395) | Yes | ||
| Bone | 235 (61–1804) | Yes | |||
| Serum | 6044 (2944–16 542) | Yes |
AUC = area under the serum concentration curve; HPLC = high-pressure liquid chromatography; MIC = minimum inhibitory concentration.
*
Serum = mg*min/L; bone = μg × min/g.