FIG. 5.

Attenuated recombinants provide protection from lethal influenza virus challenge. Average daily weights of mice inoculated with VSV recombinants and challenged with influenza virus A/WSN are shown. (A) Mice were inoculated intranasally with VSV-HA (n = 5) or CT1-HA (n = 5) at 5 × 10⁴ PFU/mouse on day 0. The mice were boosted with an equal amount of inoculum on day 21. The mice were challenged with a lethal dose of influenza virus A/WSN on day 35. (B) Conditions were the same as for panel A, except the mice were inoculated and boosted with VSVΔG (n = 4) or VSVΔG-HA (n = 5) at 5 × 10⁴ PFU/mouse. The error bars indicate ±0.5 × standard deviation.