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Immunogenicity of recombinant VSVs
| Inoculuma | Serum neutralizing antibody titer to:
|
|||
|---|---|---|---|---|
| influenza virus A/WSN
|
VSV Day 47d
|
|||
| Day 18b | Day 32c | Day 47d | ||
| VSV-HA | 1:512 | 1:2,048 | 1:4,096 | 1:512 |
| CT1-HA | 1:32 | 1:128 | 1:2,048 | 1:512 |
| ΔG-HA | ≤1:8 | 1:16 | 1:1,024 | ≤1:8 |
| ΔG | ≤1:8 | ≤1:8 | ≤1:8c | |
Dose, 5 × 104 PFU.
Prior to boost.
Prior to challenge.
After challenge.
