TABLE 4.
Effect of a second (boosting) inoculation
| Inoculuma | Mouse no. | Serum neutralizing antibody titer to influenza virus A/WSN
|
||
|---|---|---|---|---|
| Day 18b | Day 32c | Day 32d | ||
| VSV-HA | 1 | 1:1,024 | 1:4,096 | |
| 2 | 1:256 | 1:1,024 | ||
| 3 | 1:512 | 1:2,048 | ||
| 4 | 1:128 | 1:2,048 | ||
| 5 | 1:1,024 | 1:4,096 | ||
| 6 | 1:512 | 1:4,096 | ||
| 7 | 1:512 | 1:1,024 | ||
| 8 | 1:512 | 1:4,096 | ||
| CT1-HA | 1 | 1:32 | 1:128 | |
| 2 | 1:64 | 1:256 | ||
| 3 | 1:128 | 1:256 | ||
| 4 | 1:64 | 1:512 | ||
| 5 | 1:64 | 1:512 | ||
| 6 | 1:64 | 1:256 | ||
| 7 | 1:64 | 1:256 | ||
| 8 | 1:64 | 1:512 | ||
| ΔG-HA | 1 | ≤1:8 | 1:8 | |
| 2 | ≤1:8 | 1:256 | ||
| 3 | ≤1:8 | 1:256 | ||
| 4 | ≤1:8 | 1:32 | ||
| 5 | ≤1:8 | 1:8 | ||
| 6 | ≤1:8 | 1:8 | ||
| 7 | ≤1:8 | ≤1:8 | ||
| 8 | ≤1:8 | 1:16 | ||
| ΔG | 1–8 | ≤1:8 (8 mice) | ≤1:8 (4 mice) | ≤1:8 (4 mice) |
a
Dose, 104 PFU.
b
Following single inoculation.
c
Following single inoculation.
d
Following boost at day 21.