TABLE 5.
Dosage of CT1-HA necessary to confer a measurable antibody response
| Inoculum | Serum neutralizing titer to influenza virus A/WSNa at dose of:
|
||
|---|---|---|---|
| 101 PFU/mouse | 102 PFU/mouse | 103 PFU/mouse | |
| CT1-HA | ≤1:8 (6) | ≤1:8 | 1:128 (3) |
| 1:16 | 1:256 (2) | ||
| 1:256 | 1:512 | ||
| 1:512 (2) | |||
| 1:2,048 | |||
| VSV-HA | ≤1:8 (2) | 1:32 | 1:1,024 |
| 1:64 | 1:64 | 1:2,048 (5) | |
| 1:128 (2) | 1:512 (2) | ||
| 1:2,048 | 1:1,024 | ||
| 1:2,048 | |||
a
Dilutions indicate the lowest titers for which complete inhibition of virus-associated CPE was observed. Sera were collected at 4 weeks postinoculation. The numbers in parentheses indicate the number of mice with a particular titer; no parentheses indicates the titer for a single mouse.