TABLE I.
An overview of separation efficiencies achieved with spiral microfluidic devices for a variety of cell and particle separations.a
| Application | Sample properties | Separation efficiency (%) | Reference |
|---|---|---|---|
| Particle separation | Microparticles (1.9 and 7.32 μm) | 90 | Bhagat et al.13 |
| Particle separation | Polystyrene particles (10, 15, and 20 μm) | 90 | Kuntaegowdanahalli et al.35 |
| Blood cells separation | Erythrocytes (∼7 μm) from leukocytes (10–20 μm) | 95 | Nivedita and Papautsky12 |
| Tumor cells separation | CTCs (∼10–20 μm) from RBC (∼8 μm) and leukocytes | 85 | Hou et al.40 |
| Yeast cells separation | Yeast cells (3–5 μm) from CHO (10–20 μm) | 95 | Warkiani et al.41 |
| Sperm cells separation | Sperm cells (head length: 4.79 μm) from RBC (∼9 μm) | 81 | Son et al.42 |
| Sperm cells separation | Sperm cells from RBC (∼9 μm) and WBC (∼12 μm) | 90 | Nepal et al.43 |
| Microalgae separation | Cosmarium (20–80 μm) from Chlorella vulgaris (2–10 μm) | 60–80 | Lee and Yao5 |
| Bacteria separation | E. coli from micro-particles (2.29 and 4.70 μm) | 98 | Lee et al.44 |
a
CTCs—circulating tumor cells, RBC—red blood cell, WBC—white blood cell and CHO—Chinese Hamster cells.