Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 3;51(14):7314–7329. doi: 10.1093/nar/gkad540

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 3. — Impaired DNA methylation in Zmym2^−/− over germline genes and LINE elements. (A) Swarm plot of global CpG methylation levels of individual Zmym2^+/+ and Zmym2^−/− E8.5 embryos. Two samples coloured gray were excluded from subsequent analysis. (B) Metaplot of CpG methylation over TSS of 95 upregulated genes in Zmym2^−/− embryos expressed from annotated TSS. (C) Heatmap of DNA methylation within 500 bp of the TSS of each of upregulated gene is indicated for each E8.5 embryo. Transposon-fusion genes and the Y-chromosomal gene Uba1y are excluded. (D) Metaplot of DNA methylation over all full-length (>6 kb) L1MdT elements in the genome. (E) Expression of each gene in the given category is shown (KO/WT) in Zmym2^−/− and Dnmt3a^−/− Dnmt3b^−/−. Note that most genes upregulated in Zmym2^−/− show elevated expression in Dnmt double knockout. (F) Volcano plot of differentially expressed transposable elements comparing Dnmt3a^−/− Dnmt3b^−/− and control E8.5 embryos.