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. 2023 Jun 23;51(14):7205–7219. doi: 10.1093/nar/gkad544

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — TFs regulating MLS-associated genes expression and their evolutionary changes. (A) Top 10 transcription factor targets that were overrepresented in the genes whose expression in the brain negatively correlated with species MLS. (B) The bar graph shows the odds ratios of consensus REST target genes in the genes whose expression in the brain correlated with species MLS. (C) The plots show the odds ratio of genes containing at least one motif of the indicated TFs in their 1000 bp promoter regions. * FDR < 0.05 [Fisher's exact test for (A, B), and Spearman correlation test for (C)].