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. 2023 Jul 24;25(8):1185–1195. doi: 10.1038/s41556-023-01184-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Replicate correlation analyses of the H3K4me1 and H3K27ac MINT-ChIP show strong correlation between each duplicate sample across all time points. b, Boxplot of H3K27ac signals at opening SOX9 peaks overtime. Note that the signal increases gradually from W1 to W12. n = 2 biological replicates. Boxplot is centered at median and bound by 1st and the 3rd quartile, and whiskers extend to 1.5 times IQR on both ends. c, Profile plot (top) and heatmap (bottom) showing the H3K4me1 signals at all SOX9 Cut-and-Run peaks across time points. Note the strong flanking pattern of the H3K4me1 signals adjacent to each SOX9 binding site (center dip) from W1 to W12. d, Boxplot of H3K4me1 domain sizes at opening SOX9 peaks and SOX9 bound static peaks shows gradual increase of H3K4me1 domain size from W1 to W2 after SOX9 induction. n = 2 biological replicates. Boxplots are centered at median and bound by 1st and the 3rd quartile, and whiskers extend to 1.5 times IQR on both ends.