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. 2023 Jul 24;25(8):1185–1195. doi: 10.1038/s41556-023-01184-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, Upset plot shows % of peaks bound by SOX9 in the top peak sets from Fig. 2d. Note that peaks opened by W2 are more often bound by SOX9 than later opening or closing peaks. b, GO terms enriched in SOX9-bound opening peaks (C2, C4, C5) and all closing peaks (C1,C6). c, ATAC footprint analysis at D0 and W2 shows a decrease in chromatin accessibility at GATA footprint in dynamic ATAC peaks following SOX9 induction. d, EpdSCs expression of TFs that belong to TF families whose motifs are enriched in closing ATAC peaks (C1 and C6 in Fig. 3c) (binomial is used to calculate the significance). e, (top) Transcript levels of Gata3 over time following SOX9 induction. (bottom) GATA3 immunofluorescence of epidermis at D0, W6 and W12. Scale bars, 50μm. f, Integrative Genomics Viewer (IGV) snapshot of SOX9, ATAC and H3K4me1 tracks within the Gata3 locus. The red box indicates a peak >30kb downstream from the gene that is bound by SOX9 and MLL3/4, and stays open at W2 even though the gene body of Gata3 closes its chromatin (see Fig. 5b).