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. 2023 Jul 13;25(8):1101–1110. doi: 10.1038/s41556-023-01178-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — a−c, Lipidomic profiles of the AAV-infected M1 cortices. Lipids were extracted from tissues using an MTBE method and analyzed by LC-MS/MS positive ion mode. Absolute amounts of detected TG species, normalized by tissue weight (a). Relative fold changes of CE (b) and DAG (c) lipid classes. Box-and-whisker plot, Median ± the 25^th to 75^th percentiles, the whiskers extended to the minima and the maxima, n = 6 mice, **p < 0.01, ***p < 0.001, ****p < 0.0001 (a, 58:7 = 0.000754, 56:7 = 0.000393, 56:6 = 0.000444, 56:5 = 0.000738, 54:6 = 0.000463, 54:5 = 0.000426, 54:4 = 0.000849, 52:2 = 0.000516, 52:1 = 0.000452, 50:1 = 0.000688, 50:0 = 0.000782, 48:0 = 0.001107, 60:8 = 0.001432, 60:7 = 0.001566, 58:8 = 0.000339, 58:6 = 0.00057, 58:5 = 0.001099, 56:8 = 0.000765, 56:4 = 0.00035, 56:1 = 0.001576, 55:7 = 0.012073, 55:4 = 0.011659, 54:0 = 0.00632, 54:7 = 0.00109, 54:3 = 0.000166, 54:2 = 0.004482, 53:1 = 0.00169, 53:0 = 0.002413, 52:6 = 0.00086, 52:5 = 0.000911, 52:4 = 0.000621, 52:3 = 0.002428, 52:0 = 0.000684, 51:0 = 0.008827, 50:4 = 0.008494, 50:2 = 0.002913; c, 40:6 = 0.000276, 38:6 = 0.000118, 38:5 = 0.003104, 36:4 = 0.000045, 34:1 = 0.00001, 34:0 = 0.006981, 32:0 = 0.000003), Two-tailed unpaired t-test on each row, multiple comparisons test using the two-stage step-up method of Benjamini, Krieger and Yekutieli. Source numerical data are available in source data.

Source data