Table 1.
Acute toxicity study of the aqueous extract of Ferula communis administered orally and intraperitoneally in mice.
| Dose (g/kg BW) | Sex |
Administration route |
|||||
|---|---|---|---|---|---|---|---|
|
Oral |
Intraperitoneal |
||||||
| D/T | Latency | Toxic symptoms | D/T | Latency | Toxic symptoms | ||
| Control | Male | 0/5 | – | None | 0/5 | – | None |
| Female | 0/5 | – | None | 0/5 | – | None | |
| 0.1 | Male | 0/5 | – | None | 0/5 | – | None |
| Female | 0/5 | – | None | 0/5 | – | None | |
| 0.5 | Male | 0/5 | – | None | 0/5 | – | None |
| Female | 0/5 | – | None | 0/5 | – | None | |
| 1.0 | Male | 0/5 | – | None | 0/5 | – | None |
| Female | 0/5 | – | None | 0/5 | – | None | |
| 1.5 | Male | 0/5 | – | None | 1/5 | > 48 h, < 72 h | Ataxia, hypoactivity, |
| Female | 0/5 | – | None | 1/5 | > 48 h, < 72 h | Ataxia, hypoactivity, | |
| 2.0 | Male | 0/5 | – | None | 2/5 | > 48 h, < 72 h | Anorexia, Ataxia, hypoactivity, piloerection. |
| Female | 1/5 | > 72 h, < 96 h | Anorexia, Ataxia, hypoactivity,piloerection | 3/5 | > 24 h, < 48 h | Anorexia, Ataxia, hypoactivity, piloerection. | |
| 2.5 | Male | 0/5 | – | None | 2/5 | > 24 h, < 48 h | Anorexia, Ataxia, hypoactivity, piloerection, asthenia, convulsions. |
| Female | 1/5 | > 72 h, < 96 h | Anorexia, Ataxia, hypoactivity, piloerection. | 3/5 | < 12 h | Anorexia, Ataxia, hypoactivity, piloerection, asthenia, convulsions. | |
| 3 | Male | 0/5 | – | None | 3/5 | < 12 h | Anorexia, Ataxia, hypoactivity, piloerection, Lethargy, asthenia, asthenia, convulsions, |
| Female | 2/5 | > 48 h, < 72 h | Anorexia, Ataxia, hypoactivity, syncope. | 5/5 | < 12 h | Anorexia, Ataxia, hypoactivity, piloerection, Lethargy, asthenia, convulsions, syncope. | |
| Dose (g/kg BW) | Sex |
Administration route |
|||||
|---|---|---|---|---|---|---|---|
|
Oral |
Intraperitoneal |
||||||
| D/T | Latency | Symptoms | D/T | Latency | Symptoms | ||
| 3.5 | Male | 0/5 | – | None | 4/5 | < 12h | Anorexia, Ataxia, hypoactivity, piloerection, Lethargy, asthenia, convulsions, syncope. |
| Female | 3/5 | > 12h, < 24h | Anorexia, Ataxia, hypoactivity, syncope, | 5/5 | > 1h, < 2h | Anorexia, Ataxia, hypoactivity, Lethargy, asthenia, convulsions, syncope. | |
| 4 | Male | 2/5 | > 12h, < 24h | diarrhea with stools and urine deeply yellow, atypical locomotion (back limbs falling), syncope. | 5/5 | > 1h, < 2h | Anorexia, Ataxia, hypoactivity, Lethargy, asthenia, convulsions, syncope. |
| Female | 5/5 | > 12h, < 24h | Anorexia, Ataxia, hypoactivity, Lethargy, asthenia, convulsions | 5/5 | > 1h, < 2h | Anorexia, Ataxia, hypoactivity, Lethargy, asthenia, convulsions, syncope. | |
D/T = dead/treated mice; none = no toxic symptoms during the observation period; mortality latency = time to death (in hours) after the injection. Latency time elapsed between administration and death.