Table 2.
Association Between Handgrip Strength, Lung Function airway inflammation and hyperreactivity.
| Outcome | All | Male | Female | |||
|---|---|---|---|---|---|---|
| β Estimate (95%CI) | P value | β Estimate (95%CI) | P value | β Estimate (95%CI) | P value | |
| FEV1 (L)† | 0.015 (0.009; 0.022) | < 0.001 | 0.012 (0.003; 0.022) | 0.009 | 0.02 (0.009; 0.031) | < 0.001 |
| FVC (L)† | 0.017 (0.009; 0.024) | < 0.001 | 0.013 (0.002; 0.023) | 0.023 | 0.023 (0.011; 0.035) | < 0.001 |
| MMEF (L)† | 0.015 (0; 0.029) | 0.053 | 0.012 (−0.007; 0.032) | 0.208 | 0.016 (−0.009; 0.041) | 0.203 |
| FEV1/FVC† | 0 (−0.001; 0.001) | 0.905 | 0.0 (−0.001; 0.002) | 0.895 | 0.0 (−0.002; 0.002) | 0.724 |
| sRaw (kPa/s)† | −0.001 (−0.005; 0.004) | 0.745 | −0.002 (−0.007; 0.003) | 0.473 | 0.002 (−0.006; 0.011) | 0.574 |
| Exp (β Estimate) (95%CI) | P value | Exp (β Estimate) (95%CI) | P value | Exp (β Estimate) (95%CI) | P value | |
|---|---|---|---|---|---|---|
| FeNO (ppb)‡ | 0.999 (0.989; 1.009) | 0.857 | 1.000 (0.989; 1.014) | 0.965 | 0.995(0.975; 1.014) | 0.622 |
| PD20 (mcg)‡ | 1.016 (0.989; 1.042) | 0.234 | 1.023 (0.989; 1.059) | 0.198 | 1.041 (0.951; 1.14) | 0.388 |
Multiple linear regression was used for continuous outcomes† and multiple log-linear regression was used for log transformed continuous outcomes‡ . All analyses are adjusted for age, height, and weight. Analyses performed on the overall group are further adjusted for sex.
Key: FeNO = Fractional Exhaled Nitric Oxide, FEV1 = Forced Expiratory Volume 1 second, FVC = Forced Vital Capacity, HGS = Handgrip Strength, MMEF = Maximal Mid-expiratory Flow, PD20 = Provocation Dose of methacholine causing a drop of 20% in FEV1, sRaw = Specific Airway Resistance.