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. 2023 Aug 11;8:296. doi: 10.1038/s41392-023-01542-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Transcriptome analysis of MHCII^hi and MHCII^low neutrophils isolated from the lungs of tumor-bearing mice with chronic PAO1 infection. a Volcano plot showing differential gene expression between MHCII^hi and MHCII^low neutrophils in the lungs of 4T1-bearing mice with chronic PAO1 infection. Genes with a fold change higher than 2 and a P value of <0.05 are highlighted in blue and red, denoting down- and upregulated genes, respectively, in MHCII^hi and MHCII^low neutrophils. b GO enrichment in MHCII^hi and MHCII^low neutrophils in the lungs of 4T1-bearing mice with chronic PAO1 infection. c Reactome pathway analysis of the enriched genes identified from MHCII^hi and MHCII^low neutrophils in the lungs of 4T1-bearing mice with chronic PAO1 infection. d Average expression levels of genes involved in extracellular matrix remodeling, reactive oxygen species, immunosuppression, anti-inflammation, angiogenesis, and tumor proliferation in MHCII^hi and MHCII^low neutrophils in the lungs of 4T1-bearing mice with chronic PAO1 infection