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. 2023 Aug 10;14:4819. doi: 10.1038/s41467-023-40524-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Comparison of the ligand-binding pockets of α_1A-AR and α_1B-AR. b Hydrophobic interaction between the methanesulfonamide group of A61603 and the three residues V185, A189, and M292 of α_1A-AR. c Steric clash between the docked A61603 and α_1B-AR.