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. 2023 Aug 10;13:13042. doi: 10.1038/s41598-023-40107-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Top 3 significant DTU genes in the comparison of MIS LBSL cells versus control cells. Bar plots of proportions of each transcript per cell (mean proportion fit: short red line). Significant DTU transcripts are represented as red fonts. (A) The expression of SLIRP was downregulated in MIS cells, and DTU analysis revealed the switching from protein-coding to nonsense mediated decayed transcripts, indicating that dysregulated splicing may have led to the decreased gene expression. (B) DTU analysis further elucidated that LBSL cells not only had higher transcript usage of protein coding transcripts of TPD52L1, (TPD52L1-204 and TPD52L1-207) but also of intron-retaining transcripts (TPD52L1-205). (C) Finally, DTU analysis indicated MORF4L1 switching from transcripts with long 3' untranslated region (UTR) to transcripts with short 3’ UTR.