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Simplified diagram depicting the FAS pathway involved in activation-induced cell death (AID). FAS ligand (FASL) binds FAS, causing clustering of FAS. This recruits FAS-associated protein with death domain (FADD) and Pro-Caspases 8 and 10, which together with FAS constitute the death-inducing signaling complex (DISC). The DISC then propagates a pro-apoptotic signal via the activation of terminal caspases.
