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. Author manuscript; available in PMC: 2023 Aug 11.
Published in final edited form as: Arch Pathol Lab Med. 2019 Apr 8;144(2):245–251. doi: 10.5858/arpa.2018-0190-RS

Figure 2.

Figure 2.

Lymph nodes in autoimmune lymphoproliferative syndrome (ALPS) patients often show characteristic changes. A-B) Enlarged lymph node with a florid follicular hyperplasia composed of small mature-appearing lymphocytes (hematoxylin-eosin, original magnification ×2 and ×10). C) The paracortical lymphocytes are highly proliferative (arrowheads), and may be associated with both immunoblasts (arrows) and plasma cells (circled) (hematoxylin-eosin, original magnification ×100). D) Sinus histiocytosis with emperipolesis (arrow heads) may be seen in a minority of cases (hematoxylin-eosin, original magnification ×100).