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. Author manuscript; available in PMC: 2023 Aug 11.
Published in final edited form as: Arch Pathol Lab Med. 2019 Apr 8;144(2):245–251. doi: 10.5858/arpa.2018-0190-RS

Figure 4.

Figure 4.

Diagnostic algorithm for autoimmune lymphoproliferative syndrome (ALPS). A presumptive diagnosis of ALPS may be rendered based on clinical history and the results of laboratory testing. A definitive diagnosis requires genetic testing and potentially functional assays. Genetic testing can be performed in a stepwise fashion and may incorporate multigene panels. *** = diagnosis depends on results of multigene testing; IL = interleukin; NGS = next generation sequencing; DNT = double negative T; sFAS = somatic FAS; FASL = FAS ligand; CASP10 = Caspase 10.