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The inhibitory activities of ciprofloxacin hybrids 2a-c, 2e-f, 5a-c, 5e-i and ciprofloxacin on S. aureus DNA gyrase
| Compound | S. aureus DNA gyrase |
|---|---|
| IC50 ± SD (µM) | |
| 2a | 3.469 ± 0.18 |
| 2b | 0.231 ± 0.01 |
| 2c | 2.995 ± 0.16 |
| 2e | 3.810 ± 0.20 |
| 2f | 1.770 ± 0.09 |
| 5a | 4.546 ± 0.24 |
| 5b | 1.272 ± 0.07 |
| 5c | 1.567 ± 0.08 |
| 5e | 1.012 ± 0.05 |
| 5f | 3.505 ± 0.19 |
| 5g | 7.592 ± 0.40 |
| 5h | 1.456 ± 0.08 |
| 5i | 1.414 ± 0.07 |
| Ciprofloxacin | 0.323 ± 0.02 |
