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. 2023 Jul 20;15(14):6969–6992. doi: 10.18632/aging.204886

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Copyright: © 2023 Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Construction and evaluation of the 6-gene signature. (A) The multivariate Cox risk model of 6 genes. (B) OS curves of the two risk subgroups (HR = 1.9, p-value < 0.001). (C) The distribution of risk scores, survival times and outcomes of LUSC patients. (D) Receiver operating characteristic (ROC) curves for 2-, 4- and 6-year of TCGA-LUSC cohort. (E, F) Univariate and multivariate Cox regression analyses of the risk model and other clinic-pathological factors. (G–I) External validation in GEO database (GSE30219, GSE157011, and GSE3141).