FIGURE 3.
Dose‐dependent tumour growth inhibition induced by Escherichia coli OMVs. (a) Experimental procedure to evaluate OMV‐induced anti‐tumour responses. C57BL/6 and Balb/c mice were subcutaneously inoculated with MB49 and EMT6 cells, respectively. When the tumour volume reached about 100 mm3, indicated dosage of OMVs was intratumorally administered four times in 3 days interval. (b, c) Tumour volume was measured every 2 days. n = 11 for each dosage of OMVs. **p < 0.01, ****p < 0.0001 calculated by two‐way ANOVA with Bonferroni correction for multiple comparisons.