Table 1.

Characteristics of included studies

	Study name	Countries	Study type	Study years	Type of serodiscordant couples	Number of couples	Number of linked transmissions during study
Bavinton et al (2018)18	Opposites Attract	Australia, Brazil, and Thailand	Cohort	2012–16	100% male–male couples	358	0
Cohen et al (2016)19	HPTN 052	Nine countries worldwide	RCT	2005–10	97% male–female couples and 3% unspecified	1763	46
Fideli et al (2001)25	..	Zambia	Nested case-control within prospective cohort	1994–2000	100% male–female couples	1022 (case-control: 109 index transmitters and 208 non-transmitting controls)	129
Mujugira et al (2016)26	Partners PrEP Study	Kenya and Uganda	Analysis of couples in placebo arm of RCT	2008–12	100% male–female couples	1573	Index not on ART: 55; index on ART: 3
Quinn et al (2000)20	Rakai	Uganda	RCT	1994–98	100% male–female couples	415	90*
Rodger et al (2016)21	PARTNER	14 European countries	Cohort	2010–14	62% male–female couples and 38% male–male couples	1166	None
Rodger et al (2019)22	PARTNER2	14 European countries	Cohort	2010–17	100% male–male couples	972	None
Tovanabutra et al (2002)27	..	Thailand	Cross-sectional study of wives of HIV-positive men	1992–98	100% male–female couples	493	44% of female partners found to have an HIV-positive serostatus at enrolment*

ART=antiretroviral therapy. RCT=randomised controlled trial.

^*Phylogenetic linkage analysis not conducted.