Table 1.
Association of rs9357152 and rs4243652 with case-control status.
| Stratum |
rs9357152 (HPV16+ve) |
rs4243652 (HPV18+ve) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ncases | Ncontrols | NTotal | OR | p | Ncases | Ncontrols | NTotal | OR | p | |
| Overall | 307 | 561 | 868 | 1.16 (0.93–1.43) | 0.19 | 88 | 558 | 646 | 1.56 (0.79–3.09) | 0.20 |
| LSIL (CIN1 + CIN2< 30y) | 19 | 561 | 580 | 0.52 (0.21–1.24) | 0.14 | 4 | 558 | 562 | n.a. | |
| HSIL (CIN2≥30y + CIN3) | 89 | 561 | 650 | 1.01 (0.71–1.43) | 0.97 | 11 | 558 | 569 | 1.11 (0.15–8.40) | 0.92 |
| Invasive | 197 | 561 | 758 | 1.33 (1.03–1.70) | 0.03 | 73 | 558 | 631 | 1.72 (0.84–3.52) | 0.14 |
| - Adenocarcinoma | 19 | 561 | 580 | 1.58 (0.81–3.07) | 0.18 | 27 | 558 | 585 | 2.96 (1.18–7.41) | 0.02 |
| - Squamous carcinoma | 165 | 561 | 726 | 1.25 (0.96–1.64) | 0.10 | 43 | 558 | 601 | 1.13 (0.40–3.23) | 0.81 |
Stratified logistic regression analyses restricted to the disease type. Cervical intraepithelial neoplasia was differentiated into LSIL/low-risk (CIN1 + CIN2<30) and HSIL/high-risk (CIN2≥30 + CIN3) groups. Invasive cervical cancer was stratified into squamous epithelial cell carcinoma or adenocarcinoma. High-risk dysplasia (CIN2≥30 + CIN3) and invasive cancer were also combined together. For the LSIL analysis for rs4243652, numbers of HPV 18 positive samples were too small for statistical analysis. CI, confidence interval; OR, odds ratio for minor allele; P, P value from logistic regression analysis.