Table 2.
Association results for rs9357152 and rs4243652 in distinct control groups.
| Control series |
rs9357152 (HPV16+ve invasive cancer) |
rs4243652 (HPV18+ve adenocarcinoma) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ncases | Ncontrols | NTotal | OR | p | Ncases | Ncontrols | NTotal | OR | p | |
| Control group 1 | 197 | 561 | 758 | 1.33 (1.03–1.70) | 0.03 | 27 | 558 | 585 | 2.96 (1.18–7.41) | 0.02 |
| Control group 2 | 197 | 379 | 576 | 1.16 (0.89–1.50) | 0.27 | 27 | 379 | 406 | 2.72 (1.02–7.18) | 0.04 |
| Control group 3 | 197 | 129 | 326 | 1.32 (0.94–1.86) | 0.11 | 27 | 119 | 146 | 1.30 (0.49–3.44) | 0.60 |
| Controls combined | 197 | 1069 | 1266 | 1.26 (1.00–1.58) | 0.05* | 27 | 1056 | 1083 | 2.49 (1.02–6.06) | 0.04 |
Logistic regression analyses restricted to either HPV16-positive invasive cancer (for rs9357152) or HPV18-positive adenocarcinoma (for rs4243652) and three distinct control groups. Control group 1: random controls from Cervigen, RFLP-genotyped; Control group 2: additional controls from Cervigen, array-genotyped; Control group 3: HPV-negative controls derived from cervical tissue cohort, RFLP-genotyped. CI, confidence interval; OR, odds ratio for minor allele; P, P value from logistic regression analysis. *Exact P value 0.049.