Fig. 2.

Sliding window correlations between brain measures in the TLE population as a function of the age of epilepsy onset. Panel A) shows the association between SWM-MD and hippocampal volume in the ipsilateral hemisphere for the three main groups of regions. Panel B) shows the association between ipsilateral cortical thickness and SWM-MD for the three main groups of regions. Panel C) shows the same association between contralateral cortical thickness and SWM-MD for the same groups of regions. The blue lines display the correlation coefficients’ fluctuation value across age of epilepsy onset, and the blue shading indicates when the relation is significant (p <0.05). To ensure stability of the results, a bootstrapping analysis was applied to a random rank order of values to verify that the correlation values obtained were not due to chance. Thus, the p-values in the figure are uncorrected at each instance, reflecting the approach already described by Allen et al. (2014) and Shakil et al. (2018). A plot with the mean (±standard deviation) of the age of onset for each window is reported in Supplementary Figure 5. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)