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. 2023 Jul 27;10:1203669. doi: 10.3389/fnut.2023.1203669

Table 6.

Association between intake of total dietary fiber and development delay at the age of 3 years in mothers who took daily folic acid supplements during pregnancy.

Subscales in ASQ-3 Communication Gross motor Fine motor Problem solving Personal-social
cOR (95% CI) aOR (95% CI) cOR (95% CI) aOR (95% CI) cOR (95% CI) aOR (95% CI) cOR (95% CI) aOR (95% CI) cOR (95% CI) aOR (95% CI)
Total dietary fiber (g/1,000 kcal/day)
Q5 (≥7.86) 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
Q4 (6.62– < 7.86) 1.25 (0.96–1.62) 1.32 (0.98–1.72) 1.02 (0.81–1.29) 1.00 (0.76–1.26) 1.09 (0.90–1.33) 1.09 (0.88–1.36) 1.16 (0.95–1.41) 1.16 (0.94–1.44) 1.17 (0.90–1.54) 1.15 (0.85–1.56)
Q3 (5.74– < 6.62) 1.40 (1.08–1.81) 1.45 (1.09–1.94) 1.29 (1.03–1.61) 1.34 (1.05–1.72) 1.40 (1.16–1.68) 1.39 (1.12–1.72) 1.31 (1.06–1.55) 1.25 (1.01–1.55) 1.24 (0.95–1.61) 1.23 (0.91–1.66)
Q2 (4.84– < 5.74) 1.53 (1.19–1.97) 1.63 (1.23–2.17) 1.12 (0.89–1.40) 1.15 (0.89–1.48) 1.32 (1.09–1.59) 1.37 (1.10–1.70) 1.30 (1.09–1.60) 1.31 (1.05–1.62) 1.30 (1.00–1.69) 1.35 (1.00–1.82)
Q1 (< 4.84) 1.47 (1.14–1.89) 1.65 (1.23–2.19) 1.09 (0.87–1.38) 1.12 (0.86–1.45) 1.52 (1.26–1.83) 1.54 (1.25–1.91) 1.52 (1.26–1.83) 1.54 (1.25–1.90) 1.45 (1.12–1.88) 1.44 (1.07–1.93)
P for trend 0.001 < 0.001 0.264 0.192 < 0.001 < 0.001 < 0.001 < 0.001 0.004 0.008

cOR, crude odds ratio; aOR, adjusted odds ratio; CI, confidence interval; ASQ-3, Ages and Stages Questionnaires, Third Edition. Boldface indicates significance (p < 0.05).

Adjusted for maternal smoking and drinking during pregnancy, maternal age at birth, pre-pregnancy BMI, maternal and paternal education levels, annual household income, child sex, mode of delivery, birthweight, gestational age at birth, older siblings, attendance a childcare facility at 1 year of age, breastfeeding until 1 year of age, mother's K6 scores during pregnancy and when her child was 1 year of age, caretaker other than the child's mother at 1 year of age, and attachment bond when her child was 1 year of age.