Table 2.
Irritable bowel syndrome symptom severity total and domain-specific scores over the intervention period
|
Placebo (n = 104)
|
L. plantarum 1B (n = 104)
|
L. plantarum 10B (n = 99)
|
||||
|
mean (SD)
|
mean (SD)
|
P vs Placebo1
|
mean (SD)
|
P vs Placebo1
|
P vs 1B dose2
|
|
| IBS-SSS total score | ||||||
| Day 0 | 308.70 (70.91) | 315.95 (62.07) | 302.85 (61.06) | |||
| AbsΔ (Day 28) | -35.68 (60.81) | -66.37 (72.27) | 0.0098 | -85.80 (89.53) | < 0.0001 | 0.0956 |
| AbsΔ (Day 56) | -58.82 (74.75) | -128.45 (83.30) | < 0.0001 | -156.77 (99.06) | < 0.0001 | 0.0298 |
| Abdominal pain severity | ||||||
| Day 0 | 67.05 (17.11) | 68.80 (13.40) | 67.07 (13.77) | |||
| AbsΔ (Day 28) | -9.24 (19.67) | -15.45 (18.36) | 0.0830 | -20.76 (22.76) | < 0.0001 | 0.0736 |
| AbsΔ (Day 56) | -14.38 (21.18) | -28.91 (20.36) | < 0.0001 | -36.52 (24.39) | < 0.0001 | 0.0176 |
| Abdominal pain duration | ||||||
| Day 0 | 41.11 (14.13) | 42.60 (14.55) | 39.37 (13.75) | |||
| AbsΔ (Day 28) | -5.35 (13.50) | -8.46 (12.05) | 0.1975 | -7.89 (12.62) | 0.0484 | 0.7463 |
| AbsΔ (Day 56) | -8.38 (13.75) | -15.29 (13.72) | 0.0006 | -19.68 (14.91) | < 0.0001 | 0.0315 |
| Abdominal distension | ||||||
| Day 0 | 65.08 (18.11) | 66.31 (15.11) | 63.07 (14.34) | |||
| AbsΔ (Day 28) | -8.66 (18.19) | -14.69 (17.68) | 0.0600 | -18.55 (22.62) | < 0.0001 | 0.1849 |
| AbsΔ (Day 56) | -14.00 (20.76) | -29.33 (21.64) | < 0.0001 | -35.45 (24.00) | < 0.0001 | 0.0598 |
| Bowel habits | ||||||
| Day 0 | 68.32 (15.64) | 69.35 (13.70) | 66.72 (14.55) | |||
| AbsΔ (Day 28) | -6.45 (12.02) | -14.36 (18.66) | 0.0020 | -19.52 (21.48) | < 0.0001 | 0.0714 |
| AbsΔ (Day 56) | -11.19 (16.63) | -27.73 (19.54) | < 0.0001 | -32.31 (25.12) | < 0.0001 | 0.1561 |
| Effect on quality of life | ||||||
| Day 0 | 67.13 (15.85) | 68.90 (14.47) | 66.62 (12.85) | |||
| AbsΔ (Day 28) | -5.97 (12.03) | -13.40 (17.48) | 0.0060 | -19.08 (21.13) | < 0.0001 | 0.0395 |
| AbsΔ (Day 56) | -10.86 (15.74) | -27.19 (19.19) | < 0.0001 | -32.81 (23.66) | < 0.0001 | 0.0690 |
1
ANCOVA using Dunnett’s test adjustment with treatment as factor and baseline as covariate vs placebo.
2
Two-sample t-test comparing dose groups.
IBS-SSS: Irritable bowel syndrome-severity scoring system; AbsΔ: Absolute change; L. plantarum: Lactiplantibacillus plantarum.