Table 3.
Abdominal pain severity, quality of life, and perceived stress scores over the intervention period
|
Placebo (n = 104)
|
L. plantarum 1B (n = 104)
|
L. plantarum 10B (n = 99)
|
||||
|
mean (SD)
|
mean (SD)
|
P vs Placebo1
|
mean (SD)
|
P vs Placebo1
|
P vs 1B dose2
|
|
| APS-NRS score | ||||||
| Day 0 | 7.14 (0.69) | 7.14 (0.77) | 7.17 (0.86) | |||
| AbsΔ (Day 28) | -0.61 (1.12) | -0.87 (1.06) | 0.1356 | -0.92 (0.90) | 0.0733 | 0.7089 |
| AbsΔ (Day 56) | -0.94 (1.36) | -1.83 (1.38) | < 0.0001 | -2.39 (1.47) | < 0.0001 | 0.0057 |
| IBS-QoL total score | ||||||
| Day 0 | 36.19 (17.97) | 37.83 (17.25) | 37.54 (17.02) | |||
| AbsΔ (Day 28) | 4.20 (14.19) | 8.82 (17.38) | 0.0208 | 17.65 (19.47) | < 0.0001 | 0.0009 |
| AbsΔ (Day 56) | 4.90 (14.29) | 17.47 (19.54) | < 0.0001 | 28.78 (23.64) | < 0.0001 | 0.0003 |
| PSS score | ||||||
| Day 0 | 22.06 (4.29) | 22.42 (4.12) | 21.93 (4.31) | |||
| AbsΔ (Day 28) | -0.12 (3.92) | -2.38 (4.54) | < 0.0001 | -2.76 (4.69) | < 0.0001 | 0.5690 |
| AbsΔ (Day 56) | -0.46 (4.14) | -4.33 (6.51) | < 0.0001 | -5.59 (6.43) | < 0.0001 | 0.1708 |
1
ANCOVA using Dunnett’s test adjustment with treatment as factor and baseline as covariate vs placebo.
2
Two-sample t-test comparing dose groups.
APS-NRS: Abdominal pain severity-numeric rating scale; IBS-QoL: Irritable bowel syndrome-quality of life; PSS: Perceived stress scale; AbsΔ: Absolute change; L. plantarum: Lactiplantibacillus plantarum.