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Substrate binding to CYP121 induces increased specificity in the CYP-Adx complex. 2D 1H-15N HSQC spectra of uniformly labeled 15N-Adx were acquired alone and in the presence of ligand-bound and ligand-free CYP121. The remaining peak intensity ratios resulting from 5-fold excess additions of ligand-free CYP121 (A), cYY-bound CYP121 (B), and clotrimazole-bound CYP121 (C) indicate a complex with increased specificity that results from the addition of cYY.
