Figure 9.

Candidate allosteric routes for bidirectional communication in CYP121.A, overview of CYP121 phenol coupling reaction cycle, with an emphasis on the role of bidirectional allostery induced by substrate and redox partner binding. B, route one in cyan includes the B-helix, the BC-loop, and connects to the C-helix of the proximal surface and T103C. Route two in yellow includes the N-terminal β-strand loop, connected to the meander region and T333C. Route three in orange includes the heme and the meander region at T333C. cYY is shown in red, and the S171C residue representing the FG-loop is shown in purple (B).