Fig. 5.

Integration of tissue, plasma, and urine proteomes.A, summary of molecular and pathway variations transferred from tissue to plasma and urine in early-stage ccRCC. B, proteins varied constantly in CPTAC tissue dataset, present tissue dataset, plasma dataset, and urine dataset. C and D, protein class and molecular function of 27 commonly differential proteins in tissue, plasma, and urine with the same change trend in early-stage ccRCC. E, network of these “tissue-plasma-urine consistent proteins” activate tumor cell invasion and migration, while inhibit tumor cell death, thus promoting ccRCC progression. Red, upregulated proteins; green, downregulated proteins; blue, no detected. ccRCC, clear cell renal cell carcinoma; CPTAC, Clinical Proteomic Tumor Analysis Consortium.