FIGURE 3. Genome-Wide Meta-Analytic Results of Percentage Improvement and Early Partial Response After 2 Weeks of Antidepressant Treatment in Entire Analyzed Samples From GENDEP, MARS, and STAR*D^a.

^a GENDEP=Genome-Based Therapeutic Drugs for Depression; MARS=Munich Antidepressant Response Signature; STAR*D=Sequenced Treatment Alternatives to Relieve Depression. Early partial response was defined as a 25% improvement on the Hamilton Depression Rating Scale. The y-axis plots p values for associations on the negative logarithmic scale (–log₁₀[p values]). Gene symbols indicate the gene on which the associated single-nucleotide polymorphism (SNP) (p≤5310²⁶) is located, or, if the gene symbol is in parentheses, the nearest gene up to 100 kb away from the associated SNP.