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. 2023 Jul 27;15:1168638. doi: 10.3389/fnagi.2023.1168638

FIGURE 5.

FIGURE 5

MetaGRS validation using Cox proportional hazard model in UPitt after removing APOE region. The figure shows the performance of MetaGRS in UPitt in (A) all sample; (B) APOE e4 carriers; and (C) APOE e4 non-carriers. APOE region is removed in the calculation of AD GRS. Cox proportional hazard model is performed in each sample, adjusting for age, sex and the first five principal components. C-index is used to evaluate the performance of prediction.