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RFLP of large- and small-plaque variants isolated from different tissues. DNA was digested with BamHI (lanes 1 to 4) or EcoRI (lanes 5 to 8) and electrophoresed in 0.8% agarose gels containing ethidium bromide. Lanes 1 and 5, large-plaque variant from the kidney; lanes 2 and 6, small-plaque variant from the kidney; lanes 3 and 7, large-plaque variant from the GI tract; lanes 4 and 8, small-plaque variant from the brain. Bracket indicates fragments exhibiting RFLP.
