FIG. 9.

Neuroinvasive progression of SP7 and LP5 variants in the mouse. BALB/c mice were inoculated in the right rear footpad with 5 × 10⁵ PFU of either the SP7 or LP5 variant. Mice were euthanized (three mice per time point) on 0, 1, 3, 5, 7, and 9 days p.i. The foot, sciatic nerve, DRG, spinal cord, and brain were removed, virus was extracted into 1 ml of medium, and viral titers were determined. Virus titers are representative of the amount of virus in the total tissue sample.