Table 4.
Overall Complication Rate per Treatment Option.
| Treatment Option | Studies n |
Lesions n |
Pooled Mean Age (Years) | Pooled Mean Follow-Up (Months) | Complication Rate % (95% Confidence Interval) |
|---|---|---|---|---|---|
| Overall | 178 | 6,962 | 35.5 | 46.3 | 5 (4-6) |
| Bone marrow stimulation therapies a | 67 | 2,926 | 36.7 | 48.7 | 4 (3-6) a |
| Retrograde drilling b | 14 | 289 | 32.6 | 39.2 | 5 (3-8) b |
| Fixation c | 8 | 179 | 22.3 | 35.5 | 3 (1-8) c |
| Matrix-assisted bone marrow stimulation d | 31 | 1,072 | 16.8 | 14.7 | 3 (2-4) d |
| Cartilage implantation e | 22 | 479 | 32.8 | 47.5 | 5 (3-8) e |
| Osteo(chondral) autograft transplantation therapies f | 61 | 1,639 | 34.7 | 54.2 | 8 (6-10) f |
| Osteo(chondral) allograft transplantation therapies g | 15 | 288 | 43.1 | 30.8 | 8 (4-14) g |
| Metal implants h | 3 | 80 | 41.7 | 54.4 | 15 (5-35) h |
| Other i | 1 | 10 | 43.3 | 12 | 5 (0-45) i |
Significantly different from osteo(chondral) autograft transplantation therapies (Q = 7.55, P = 0.0060) and metal implants (Q = 5.27, P = 0.0217).43,52,59,61 -63,66,81,92,93,109,113,117,121,123,125,131,135,141,143,146,149,150,153,158,164,165,167,168,171,173,176,177,179 -183,187,190,192,195 -200,202,204 -206
Significantly different from metal implants (Q = 3.86, P = 0.0493).11,42,53,56,59,116,118,137,170,177,194,196
Significantly different from osteo(chondral) autograft transplantation therapies (Q = 16.86, P < 0.0001), osteo(chondral) allograft transplantation therapies (Q = 7.66, P = 0.0056), and metal implants (Q = 9.29, P = 0.0023).29,38,40,49,58,65,72,77,82,94,98,101,130,139,140,142,144,145,155,157,162,166,169,181,189,192,195,201,204
Significantly different from metal implants (Q = 3.95, P = 0.0468).14,41,45,46,51,64,76,78 -80,86,99,103,107,112,114,115,124,133,147,179
Multiple studies: 15,36,39,47,48,50,60,68,70,71,74,75,83,84,87 -90,95 -97,100,105,106,108,110,120,126,128,129,132,136,138,148,151,152,154,156,159 -161,163,171 -175,178,184,188,191,193,194,197,203.
Study: 127 .