Table 10.
Type of SAP used as reported by 9 of 16 participating registries: DKR, FAR, JointCare, KP, NZJR, NAR, PABZ, RAR, and SAR (n = 530,495 TKAs)
| Generic name | ATC code | Registry reporting SAP | Used in TKA n (% of 517,890) a |
|---|---|---|---|
| Cefazolin | J01DB04 | JointCare, KP, NAR, NZJR, PABZ, RAR | 165,915 (32) |
| Cefuroxime | J01DC02 | DKR, FAR, JointCare, KP, NAR, NZJR, PABZ, RAR, SAR | 139,306 (27) |
| Cloxacillin | J01CF02 | FAR, NAR, SAR | 114,240 (22) |
| Cefalotin | J01DB03 | FAR, NAR | 23,404 (4.5) |
| Clindamycin | J01FF01 | FAR, JointCare, KP, NAR, NZJR, RAR, SAR | 18,716 (3.6) |
| Vancomycin | J01XA01 | DKR, FAR, JointCare, KP, NAR, NZJR, PABZ, RAR, SAR | 13,963 (2.7) |
| Cefpirome | J01DE02 | FAR, RAR | 8,652 (1.7) |
| Gentamicin | J01GB03 | JointCare, KP, NAR, NZJR, RAR | 8,620 (1.7) |
| Ceftriaxone | J01DD04 | FAR, JointCare, KP, NZJR, PABZ, RAR | 6,106 (1.2) |
| Cefotaxime | J01DD01 | NAR, PABZ, RAR, SAR | 2,475 (0.5) |
| Dicloxacillin | J01CF01 | DKR, NAR | 1,396 (0.3) |
| Cefoperazone | J01DD12 | RAR | 1,337 (0.3) |
| Cefalosporine | J01D | RAR | 1,086 (0.2) |
| Ceftazidime | FJ01DD02 | FAR, KP, PABZ, RAR | 1,056 (0.2) |
| Amoxicillin-clavulanic acid | AJ01CR02 | JointCare, RAR | 273 (0.1) |
| Oxacillin | J01CF04 | RAR | 751 (0.1) |
| Ciprofloxacin | J01MA02 | FAR, JointCare, KP, NAR, RAR, SAR | 336 (0.1) |
| Teicoplanin | J01XA02 | JointCare, PABZ, RAR | 271 (0.1) |
| Polymyxin | J01XB02 | KP | 104 (0.0) |
| Tobramycin | J01GB01 | KP | 84 (0.0) |
| Levofloxacin | J01MA12 | JointCare, KP, PABZ, RAR | 63 (0.0) |
| Piperacillin | J01CA12 | KP, RAR | 58 (0.0) |
| Cefamandole | J01DC03 | NZJR, PABZ | 54 (0.0) |
| Cefadroxil | J01DB05 | RAR | 34 (0.0) |
| Aztreonam | J01DF01 | KP | 33 (0.0) |
| Cefalexin | J01DB01 | NAR, RAR | 25 (0.0) |
| Ampicillin/sulbactam | J01CR01 | RAR, | 22 (0.0) |
| Metronidazole | J01XD01 | KP, NAR | 16 (0.0) |
| Azithromycin | J01FA10 | KP | 13 (0.0) |
| Amoxicillin | J01CA04 | NZJR, RAR | 12 (0.0) |
| Ampicillin | J01CA01 | KP, NAR, PABZ, RAR | 10 (0.0) |
| Amikacin | J01GB06 | RAR | 10 (0.0) |
| Combination of 2 or more SAP used | |||
| Cefuroxime and vancomycin | FAR | 47 (0.0) | |
| Clindamycin and other (unspecified) | FAR | 19 (0.0) | |
| Cefuroxime and other (unspecified) | FAR | 18 (0.0) | |
| Cefuroxime and clindamycin | FAR | 14 (0.0) | |
| Vancomycin and other (unspecified) | FAR | 3 (0.0) | |
| Clindamycin and vancomycin | FAR | 2 (0.0) | |
| Others (n < 10)b | 78 (0.0) | ||
| Unknownc | 9,268 (1.8) | ||
ATC = Anatomical Therapeutic Chemical Classification System.
4% (20,627) of TKAs reported by the 9 registries did not use SAP. Besides, some registries reported use of 2 or more types of SAP per procedure. These could explain the reason why the number of SAP agents used presented here differs from the total number of TKAs from the 9 registries presented in Table 9.
Penicillin G (J01CE01) (n = 3), cefepime (J01DE01) (n = 7), cefotetan (J01DC05) (n = 3), cefoxitin (J01DC01) (n = 7), piperacillin/tazobactam (J01CG02) (n = 7), flucloxacillin (J01CF05) (n = 8), meronem (J01DH02) (n = 4), ertapenem (J01DH03) (n = 6), imipenem/cilastatin (J01DH51) (n = 2), imipenem (J01DH56) (n = 2), sulfamethoxazole-trimethoprim (J01EE01) (n = 9), erythromycin (J01FA01) (n = 3), clarithromycin (J01FA09) (n = 1), norfloxacin (J01MA06) (n = 1), moxifloxacin (J01MA14) (n = 1), doxycycline (J01AA02) (n = 8), linezolid (J01XX08) (n = 5), daptomycin (J01XX09) (n = 1).
Others, but not specified or reported as unknown.