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. 2023 Jul 28;17:1186520. doi: 10.3389/fnins.2023.1186520

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Copyright © 2023 Vázquez-González and Corona.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Unilateral injection of 6-OHDA into the rat striatum reduced tyrosine hydroxylase (TH) immunoreactivity on the injection side. (A) Schematic representation of experimental procedures and timeline. (B) Photomicrographs showing TH immunoreactivity in the ipsilateral (injection side) and contralateral striatum of control rats (CN) injected with vehicle and 6-OHDA-injected rats. In the 6-OHDA group, TH immunoexpression was significantly reduced in the ipsilateral striatum (I) compared to the contralateral striatum (C). Bar = 3 mm. (C) Quantification showing a mean 33% decrease in TH immunoexpression compared to the C striatum of 6-OHDA group rats, while immunoexpression was similar between the ipsilateral and contralateral striatum of CN group rats. Results are presented as mean ± SEM of n = 8 rats per group. **p < 0.01 vs. contralateral side by Student’s t-test.