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. 2023 Jul 28;17:1186520. doi: 10.3389/fnins.2023.1186520

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Copyright © 2023 Vázquez-González and Corona.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Unilateral 6-OHDA injection induced locomotor hyperactivity that were refractory to pioglitazone (PIO) treatment. (A) Representative activity traces of CN and 6-OHDA group rats in the open field (over 10 min) on postnatal day (PN) 25 (before PIO treatment) and PN39 (after treatment with PIO). (B) 6-OHDA-lesioned rats exhibited locomotor hyperactivity compared to CN rats both before and after PIO treatment. (C) Effects of PIO on the number of arm entries and (D) percentage alternation in the Y-maze test. Spatial working memory performance in the Y-maze was not altered by 6-OHDA injection, PIO treatment or both. All results are presented as mean ± SEM of n = 8 rats per group. *p < 0.05 vs. CN group by Student’s t-test before treatment and by one-way ANOVA with post hoc Bonferroni tests after treatment.