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. 2023 Jul 28;17:1186520. doi: 10.3389/fnins.2023.1186520

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Copyright © 2023 Vázquez-González and Corona.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pioglitazone treatment upregulated Nrf2 but not catalase (CAT) expression in specific brain regions of CN and 6-OHDA group rats. Representative Western blots (A,C,E,G) and quantification (B,D,F,H) of Nrf2 and CAT proteins in the striatum (A,B), prefrontal cortex (C,D), hippocampus (E,F) and cerebellum (G,H) of CN, 6-OHDA, CN + PIO and 6-OHDA + PIO groups. β-actin was used as the gel loading control. Results presented as mean ± SEM of n = 8 rats per group, *p < 0.05 vs. CN group and ^&p < 0.05 vs. 6-OHDA group by ANOVA with post hoc Bonferroni tests.