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. 2023 Jul 27;11:1229393. doi: 10.3389/fcell.2023.1229393

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Copyright © 2023 Lin, Sun, Zhang, Zhao and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Possible role of miRNAs during SARS-CoV-2 infection. Antiviral response: regulates the expression of ACE2 and TMPRSS2 and direct binding to the viral genome. Immune evasion: interfering with host miRNA and binding site mutations. The way of miRNA works during the cytokine storm caused by SARS-CoV-2: IL-6 amplifies activation pathway and causes cytokine storm by regulating anti-inflammatory cytokine genes.